Nonparallel isometric tension response of rabbit soleus skinned muscle fibers to magnesium adenosine triphosphate and magnesium inosine triphosphate.
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Nonparallel isometric tension response of rabbit soleus skinned muscle fibers to magnesium adenosine triphosphate and magnesium inosine triphosphate
The isometric tension response of single "skinned' rabbit soleus muscle fibers to MgATP and McITP in the absence of calcium was studied. [MgATP] or [MgITP] was varied in solutions of ionic strength 0.30 and temperature 20 degrees C. Steady-state tension that developed in MgATP or MgITP solutions was a biphasic bell-shaped function of log [MgATP] or log [MgITP] which increased from zero to maxim...
متن کاملNonparallel Isometric Tension Response of Rabbit Soleus Skinned Muscle Fibers to Magnesium Adenosine Triphosphate and Magnesium Inosine Triphosphate
It has long been accepted that M g A T P is the energy source for contraction. Evidence has also accumulated indicating that M g A T P plays an important role in the regulation of contraction (Weber and Murray, 1973; Inoue and Tonomura , 1974; Godt, 1974; Orentlicher et al., 1977). In an a t tempt to better understand the dual role of ATP in contraction, several researchers have studied the eff...
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ATP depletion of erythrocytes is associated with discocyte-echinocyte transformation and accumulation of calcium. This study was undertaken to evaluate whether this shape transformation results from interaction of Ca2’, Mg2’, and ATP with structural proteins of the membrane. ATP, Mg2+, or were incorporated into ghosts during hypotonic hemolysis followed by restoration of isotonicity with NaCI a...
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ATP is a potent inhibitor of the activity of fumarase from yeast and pig heart (Ki = 0.005 mM and 0.03 mu, respectively). There is a sigmoid relation between the inhibition and the ATP concentration provided that Mg2+ is present. The sigmoid relationship is shown to be due simply to the fact that the MgATP complex does not inhibit, so that with increasing ATP concentration, the inhibition is no...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1979
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.74.2.261